Expression of exosome LncRNA MEG3 in endometrial carcinoma and its clinical significance

Objective To investigate the expression of plasma exosomes long non-coding RNA(LncRNA) maternally expressed gene3(MEG3) in endometrial carcinoma and its relationship with the pathological characteristics of patients.

Methods Thirty patients with endometrial carcinoma undergoing operation were collected as observation group.According to the high-risk factors of patients with stage Ⅰ endometrial carcinoma, the observation group was divided into 2-3 high-risk factor subgroup(group A) with 13 cases and 0-1 high-risk factor subgroup(group B) with 17 cases.Thirty patients with normal endometrium who underwent surgical treatment for hysteromyoma or adenomyoma in the same period were selected as control group.The expression level of plasma exosome LncRNA MEG3 in each group was compared.

Results The expression level of plasma LncRNA MEG3 in the observation group was significantly lower than that in the control group(P < 0.01), and the expression level of plasma exosome LncRNA MEG3 in the group A was significantly lower than that in the group B(P < 0.01).

Conclusions Plasma exosome LncRNA MEG3 is related to endometrial carcinoma lesions and pathology, and is expected to become a new biomarker for its diagnosis and treatment.