Study on the relationship between the blood glucose, blood lipid, abdominal fat, and bone mineral density based on the quantitative CT

ObjectiveTo explore the relationship between the blood glucose, blood lipids, abdominal fat, and bone mineral density(BMD) using quantitative computed tomography(QCT).

MethodsA total of 1161 healthy subjects(including 752 males and 409 females) detected by low-dose chest CT combined with QCT were selected, and divided into the 20-29, 30-39, 40-49, 50-59, 60-69 and ≥70 years old six age groups.The venous blood of all subjects were collected on an empty stomach for detecting the levels of blood glucose, total cholesterol(TC) and triglyceride(TG).The QCT was used to measure the total adipose tissue(TAT), visceral adipose tissue(VAT), subcutaneous adipose tissue(SAT) and lumbar BMD at the central level of L₂.

ResultsThe differences of the levels of blood glucose, TC, TG, VAT, SAT and BMD among different age groups in male were statistically significant(P < 0.05 to P < 0.01), and the differences of which among different age groups in female were statistically significant(P < 0.01).The levels of the blood glucose, TC, TG, VAT and SAT were negatively correlatied with BMD in male(P < 0.05 to P < 0.01), and the levels of blood glucose, TC, TG, TAT, VAT and SAT were negatively correlated with BMD in female(P < 0.01).The results of multiple linear regression analysis showed that the blood glucose and VAT were the independent influencing factors of male BMD(P < 0.05 and P < 0.01), and the levels of TC and VAT were the independent influencing factors of female BMD(P < 0.01).

ConclusionsThe blood glucose may be a negative influencing factor of male BMD, the TC may be a negative influencing factor of female BMD, and the VAT has a negative effect on BMD of different genders.