Value of multi-parameter MRI-based radiomics in distinguishing T3a stage from T3b stage of prostate cancer

ObjectiveTo investigate the value of radiomic features of multi-parameter MRI(mp-MRI) for distinguishing T3a stage from T3b stage of prostate cancer.

MethodsThe imaging data of 151 patients with T3 stage prostate cancer were retrospectively analyzed, including 110 patients with T3a stage and 41 patients with T3b stage.Using DARWIN research platform, regions of interest(ROI) were manually sketched on the transverse T2WI and ADC images to extract the radiomic features of image.The imaging data of ADC, T2WI and ADC combined with T2WI were divided into training group and verification group at the ratio of 3:1.Then the model of three groups of training group was built, and the corresponding tests were used for internal verification.The diagnostic efficacy of different sequences was analyzed by the ROC curve.

ResultsA total of 1878 imaging features were extracted by DARWIN research platform, and 6 features(2 features of ADC and 4 features of T2WI) were retained(P < 0.05).The AUC values of training group and validation group under simple T2WI or ADC sequence were 0.79, 0.71, 0.59, 0.70.The AUC value of training group under ADC combined with T2WI sequence was 0.79, and that of validation group was 0.73.

ConclusionsT2WI combined with ADC imaging radiomics has a good auxiliary value in the preoperative differential diagnosis of T3a and T3b prostate cancer, which can make up for the defect of MRI in the diagnosis of lesions less than 1 mm and provide the supplement for the invasion of seminal vesicle to obtain more clinical preoperative detailed information and provide the guidance for accurate surgery.