Correlation analysis of thyroid hormone, sex hormone, C-reactive protein and aggressive behavior in male patients with schizophrenia

Objective To investigate the effects of thyroid hormone, sex hormone and C-reactive protein(CRP) on aggressive behavior in male patients with schizophrenia.

Methods A total of 173 male patients with schizophrenia were selected and divided into the observation groupmodified overt aggression scale(MOAS) score ≥5 points, n=88 and control group(MOAS score < 5 points, n=85) according to the MOAS score.The levels of triiodothyronine(T3), thyroxine(T4), free triiodothyronine(FT3), free thyroxine(FT4), thyroid stimulating hormone(TSH), testosterone(TESTO) and estradiol(E2) in the peripheral blood of patients in the two groups were compared.The correlation between thyroid hormone, sex hormone, CRP and aggressive behavior in the observation group was analyzed.

Results There was no significant difference in the levels of FT3 and TSH between the two groups(P>0.05), and the levels of T3, T4 and FT4 in the observation group were higher than those in the control group(P < 0.05 to P < 0.01).There was no significant difference in the level of E2 between the two groups(P>0.05), and the levels of TESTO and CRP in the observation group were higher than those in the control group(P < 0.01 and P < 0.05).Pearson correlation analysis showed that the levels of T4, FT4 and TESTO in the observation group were significantly positively correlated with the total MOAS score(r=0.341, 0.274, 0.262, P < 0.01).

Conclusions The levels of T3, T4, FT4, TESTO and CRP in the peripheral blood of male schizophrenia patients with aggressive behavior increase, and the levels of T4, FT4 and TESTO are significantly positively correlated with aggressive behavior.The detection of T3, T4, FT4, TESTO and CRP levels has certain guiding significances for clinical evaluation and prevention of impulsive aggression.