Analysis of the related factors of residual lesions after cervical conization for high-grade cervical intraepithelial neoplasia

ObjectiveTo investigate the residual status and related factors of lesions after conization of high-grade cervical intraepithelial neoplasia(CIN), and explore the necessity of supplementary surgery after conization.

MethodsThe clinical data of 200 high-grade CIN(CIN Ⅱ-Ⅲ) patients treated with conization and total hysterectomy one month after surgery were retrospectively analyzed. The correlation between the age, pregnancy history, HR-HPV genotype, CIN grade, conic resection method, resection margin status and residual lesions were analyzed using univariate and logistic regression model.

ResultsOf the 200 patients, the residual lesions in the hysterectomy specimens in 98 cases(49.0%) were found, and there was not correlation between the age, birth rate, coning method and postoperative residual lesions. The CIN grade, positive preoperative HPV-16 or HPV-18 and margin status were positively correlated with the residual lesions. The results of logistic regression analysis showed that the CIN grade, positive margin and HPV-16 or HPV-18 test results were the high risk factors of residual lesions.

ConclusionsThe CIN grade, positive margin and preoperative HPV-16 or HPV-18 genotype are the reliable predictors of residual lesions after conization for high-grade CIN.