Study on the correlation between hypertensive disorder complicating pregnancy and different in vitro fertilization techniques, and pregnancy outcomes

Objective To analyze the correlation between hypertensive disorder complicating pregnancy and different in vitro fertilization techniques, and its pregnancy outcomes.

Methods The data of 546 infertility patients with in vitro fertilization were analyzed retrospectively. According to the method of fertilization, the patients were divided into the group A(313 cases with conventional in vitro fertilization-embryo transfer) and group B(233 cases with intracytoplasmic sperm injection). According to the embryo transfer cycle, the patients were divided into the group C(370 cases with embryo transfer in fresh cycle) and group D(176 cases with embryo transfer in frozen cycle). The incidence rates of hypertensive diseases during pregnancy were compared among four groups.

Results Among 546 cases, 24 cases with gestational hypertension, 28 cases with preeclampsia and no eclampsia case were identified.The incidence rate of gestational hypertension in group A(2.66%) was lower than that in B group(6.87%)(P < 0.05), and there was no statistical significance in the incidence of preeclampsia between two groups(P>0.05). There was no statistical significance in the incidence rates of gestational hypertension and preeclampsia between group C and group D(P>0.05). The differences of the total incidence rates of adverse pregnancy outcomes between group A and group B, and between group C and group D were not statistically significant(P>0.05).

Conclusions In infertile women, the intracytoplasmic sperm injection increases the risk of gestational hypertension, regardless of conventional in vitro fertilization-embryo transfer or freshness of embryo transfer.