ObjectiveTo explore the clinical value of prealbumin(PA) in the prognostic evaluation of patients with chronic heart failure(CHF).
MethodsThe CHF patients were followed up for 180 days after discharge.According to whether major adverse cardiovascular events(MACE) occurred, the patients were divided into the MACE group and non-MACE group.The general data were compared between two groups, and the influencing factors of MACE were analyzed by multivariate logistic regression.A model was built to verify the trend change of MACE with the change of PA, and the receiver operating characteristic curve was drawn to determine the optimal critical value of influencing factors.
ResultsA total of 213 patients were enrolled, which included 113 cases in the non-MACE group and 100 cases in the MACE group.The results of multivariate analysis showed that the serum level of PA decreasing and plasma N-terminal pro-B-type natriuretic peptide(NT-proBNP) level increasing were the independent risk factors of MACE(P < 0.01).According to the results of model 1(adjusting the age and body weight) and model 2(adjusting the age, body weight and NT-probNP) analysis, there was a trend in the risk of MACE at PA level(P < 0.01).The results of Kaplan-Meier curve showed that the lower the PA level was, the higher the incidence of MACE was(P < 0.01).When the PA was 191.95 mg/L, the area under the curve predicting MACE incidence was 0.810(95%CI: 0.753-0.868).
ConclusionsThe serum level of PA decreasing is closely related to the poor prognosis of CHF patients.
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