Effect of LNG-IUS on serum estrogen, progesterone, inflammatory factors, IGF-Ⅰ and the related receptors in endometrial tissue of patients with endometrial polyp electrotomy

ObjectiveTo explore the effect of levonorgestrel-releasing intrauterine system(LNG-IUS) on serum estrogen, progesterone, inflammatory factors, and on endometrial tissue insulin-like growth factor Ⅰ(IGF-Ⅰ) and the related receptor(IGF-IR) in patients undergoing endometrial polyp(EP) electrotomy.

MethodsA total of 100 EP patients were selected as the research objects, a random number table was used to divide them into observation group and control group, 50 cases in each group.The patients in control group were treated with conventional oral progesterone drugs after EP resection, and the patients in observation group were combined with LNG-IUS treatment after EP resection.The expression levels of serum estrogen receptor(ER), progesterone receptor(PR), C reactive protein(CRP), interleukin-6(IL-6), interleukin-10(IL-10) were examined, IGF-Ⅰ and IGF-ⅠR in endometrial tissue were detected and compared between the groups.

ResultsWith the prolongation of treatment, the endometrial thickness and pictorial blood loss assessment chart score in the two groups were significantly reduced, and there were statistically significant differences between the groups at different time points(P < 0.01).After 6 months, the levels of ER and PR in the uterine gland cortex and interstitium in the observation group were lower than those in the control group at the same point(P < 0.05 to P < 0.01).After treatment, the relative expressions of various inflammatory indexes, IGF-Ⅰ and IGF-ⅠR mRNA in the two groups were significantly reduced, and they were significantly lower in the observation group than those in the control group(P < 0.05 to P < 0.01).After 6 months of follow-up, there was no significant difference in the complication occurrence rate between the two groups(P>0.05).

ConclusionsAfter the resection of endometrial polyps, electrotomy, the LNG-IUS implantation can effectively reduce the levels of estrogen and progesterone in patients, relieve postoperative inflammation, and reduce IGF-Ⅰ level.It is worthy of clinical promotion.