Relationship between platelet to lymphocyte ratio, neutrophil to lymphocyte ratio and prognosis of patients with biliogenic acute pancreatitis

ObjectiveTo study the relationship between platelet to lymphocyte ratio(PLR), neutrophil to lymphocyte ratio(NLR) and the prognosis of patients with biliogenic acute pancreatitis, and to compare their value in predicting the prognosis of biliogenic acute pancreatitis.

MethodsThe clinical data of 338 patients with biliogenic acute pancreatitis diagnosed first time from January 2015 to January 2020 were retrospectively reviewed.Receiver operating curve(ROC) was used to determine the best critical value of PLR and NLR.The clinical features of patients with different levels of PLR and NLR were compared and the prognostic risk factors of biliogenic acute pancreatitis were explored.

ResultsThe best critical values of PLR and NLR were 344.7 and 17.8, respectively according to the survival status of patients.The area under ROC curve(AUC) of PLR was bigger than NLR(Z=2.03, P < 0.05).Multivariate Cox regression model showed that the death risk of patients with low PLR was 3.551 times higher than that in patients with high PLR(95%CI: 1.161-10.868), and the risk of death in patients with high NLR was 2.769 times higher than that in patients with low NLR(95%CI: 1.039-7.397).

ConclusionsPLR and NLR may be related to the prognosis of biliogenic acute pancreatitis.Compared with NLR, PLR is more accurate in predicting the prognosis of biliogenic acute pancreatitis.