Analysis of TCM syndrome types and related risk factors of diabetic nephropathy

ObjectiveTo explore the risk factors of the main traditional Chinese medicine(TCM) syndrome types in patients with diabetic nephropathy.

MethodsA total of 130 patients with diabetic nephropathy were selected as the research subjects.The age, gender, body mass and other general information of the patients were collected through a questionnaire, and the information of the four diagnostic methods(inspection, auscultation and olfaction, inquiry, pulse-taking and palpation) was collected.The frequency and frequency distribution of TCM syndrome types of diabetic nephropathy were analyzed by expert differentiation of syndromes, and the risk factors of the main TCM syndrome types of diabetic nephropathy patients were analyzed.

ResultsThe TCM syndrome types of diabetic nephropathy were mainly Qi-Yin deficiency syndrome(29.23%), spleen-kidney Yang deficiency syndrome(20.77%), Yin deficiency and dry heat syndrome(16.92%), and liver-kidney Yin deficiency syndrome(13.85%).The distribution frequency of each TCM syndrome type was in the following order: Qi-Yin deficiency syndrome >spleen-kidney Yang deficiency syndrome >Yin deficiency and dry heat syndrome >liver-kidney Yin deficiency syndrome > spleen-kidney Qi deficiency syndrome >blood stasis and toxin syndrome >Yin-Yang deficiency syndrome.There was no significant difference in the distribution of TCM syndrome types among diabetic nephropathy patients with different gender, sedentariness or not, and family history or not(P>0.05).There was significant difference in the distribution of TCM syndrome types among patients with different age, body mass index, smoking history and drinking history(P < 0.05).The results of logistic regression analysis showed that body mass index, smoking history and drinking history were the risk factors of Qi-Yin deficiency syndrome(P < 0.05 to P < 0.01), age and drinking history were the risk factors of spleen-kidney Yang deficiency syndrome(P < 0.01), body mass index was the risk factor of Yin deficiency and dry heat syndrome(P < 0.05), and smoking history was the risk factor of liver-kidney Yin deficiency syndrome in patients with diabetic nephropathy(P < 0.05).

ConclusionsThe TCM syndrome types of diabetic nephropathy are mainly Qi-Yin deficiency syndrome, spleen-kidney Yang deficiency syndrome, Yin deficiency and dry heat syndrome, and liver-kidney Yin deficiency syndrome.The distribution of TCM syndrome types of diabetic nephropathy is related to body mass index, age, smoking history and drinking history.