Analysis of the relationship between the Hcy level, ambulatory blood pressure variability and left ventricular ejection fraction in elderly patients with hypertension

ObjectiveTo investigate the relationship between the homocysteine(Hcy) level, ambulatory blood pressure variability(BPV) and left ventricular ejection fraction(LVEF) in elderly patients with hypertension.

MethodsA total of 100 elderly patients with hypertension and 100 elderly patients without hypertension were divided into the observation group and control group, respectively.The serum Hcy level, ambulatory BPV index and LVEF between two groups were compared, and the correlation between Hcy, BPV index and LVEF were analyzed.

ResultsThe serum Hcy level in observation group was significantly higher than that in control group(P < 0.01), the standard deviation of 24 h systolic blood pressure, day systolic blood pressure and night systolic blood pressure in observation group were significantly higher than those in control group(P < 0.01), there was no statistical significance in the diastolic blood pressure index between two groups(P>0.05), and the LVEF in observation group was significantly lower than that in control group(P < 0.01).The results of Pearson correlation analysis showed that the serum Hcy level was negatively correlated with LVEF(P < 0.05), and the standard deviation of 24 h systolic blood pressure, day systolic blood pressure and night systolic blood pressure were positively correlated with LVEF in elderly patients with hypertension(P < 0.05).

ConclusionsCompared with the elderly group with normal blood pressure, the level of standard deviation of serum Hcy and ambulatory systolic blood pressure are significantly high, the level of LVEF is significantly low, and there is a correlation among the three.