ObjectiveTo explore the effects of compensatory cognitive training(CCT) and medication self-management skills training(MSST) combined with staged intervention on cognitive function in adolescent patients with schizophrenia.
MethodsA total of 59 cases of adolescent schizophrenia patients were selected as research objects, who were randomly divided into observation group(n=29) and control group(n=30).The control group took routine treatment intervention, and the observation group took MSST+CCT combined staged intervention.The changes of cognitive function, mental symptoms and medication compliance before and after intervention were compared between the two groups.
ResultsIn the observation group, 7 patients(24.1%) had poor compliance with cognitive strategy exercise, and 7 patients(24.1%) had poor compliance with drug management.The length of hospital stay was positively correlated with the total number of days of taking medication(r=0.493, P < 0.01).There was a positive correlation between the total number of days of taking medication and the total number of days of CCT practice measurement(r=0.379, P < 0.05).The total number of CCT practice strategies was positively correlated with the total number of practice measurement days(r=0.450, P < 0.05).Before intervention, there were no significant differences in the total score of positive and negative symptom scale(PANSS), total score of each subscale, total score of min-mental state examination(MMSE), and total score of medication compliance between the two groups(P < 0.05).After the course, the total score of PANSS in the observation group was lower than that in the control group(P < 0.05), there were no significant differences in PANSS subscales scores, MMSE total scores and medication compliance total scores(P < 0.05).Three months after intervention, the total scores of PANSS and its subscales, MMSE and medication compliance in the observation group were better than those in the control group(P < 0.05 to P < 0.01).There were statistically significant differences between the two groups at each time point before and after intervention(P < 0.05 to P < 0.01), the PANSS total positive symptom scores of the observation group at 3 months after intervention were lower than those before intervention(P < 0.05 to P < 0.01), PANSS total positive symptom scores of the control group at 3 months of intervention were lower than those before intervention and after the end of the course(P < 0.01);the negative symptoms in the observation group were lower 3 months after intervention than before and after the course(P < 0.01), the negative symptoms in the control group were lower than those before intervention 3 months after intervention(P < 0.01);general psychiatric symptoms in both groups were lower 3 months after intervention than before and after the course(P < 0.05 to P < 0.01), MMSE total scores increased compared with those before and after intervention(P < 0.01);the scores of medication compliance in both groups at 3 months after intervention were lower than those before intervention(P < 0.01), 3 months after intervention, the compliance score of the observation group continued to decrease compared with that after the course(P < 0.01), and the amplitude of decrease and increase in observation group was higher than that in control group(P < 0.05 to P < 0.01).
ConclusionsThe combined intervention of CCT and MSST can better improve the cognitive function, psychotic symptoms and medication compliance of adolescent schizophrenia, which is worthy of clinical application.
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