Correlation between central vene-arterial partial pressure of carbon dioxide/artery-central venous oxygen content and the risk of sepsis

ObjectiveTo analyze the correlation between the central venous-arterial partial pressure of carbon dioxide/artery-central venous blood oxygen content P(cv-a)CO₂/C(a-cv)O₂ and the risk of sepsis.

MethodsA total of 169 sepsis patients were divided into the improved group(n=121) and deteriorated group(n=48) according to the outcome of treatment.The general data and laboratory indicators of the two groups were compared.Multivariate logistic regression was used to analyze the effect of various factors on the deterioration of sepsis patients, and ROC curve was used to analyze the value of P(cv-a)CO₂/C(a-cv)O₂ and other factors in predicting the deterioration of sepsis patients.

ResultsThere was no significant difference in age, gender, WBC, CRP and other clinical data between the two groups(P>0.05).But the APACHEⅡ score, PCT, LAC, P(cv-a)CO₂ and P(cv-a)CO₂/C(a-cv)O₂ in the deteriorated group were higher than those in improved group(P < 0.01), and C(a-cv)O₂ was lower than that in the improved group(P < 0.01).Multiariable logistic regression analysis showed that the APACHEⅡ score, LAC, P(cv-a)CO₂ and P(cv-a)CO₂/C(a-cv)O₂ was the independent risk factors affecting the progression of sepsis patients(P < 0.01).ROC curve showed that the effectiveness of P(cv-a)CO₂/C(a-cv)O₂ predicting the progression of the disease in the diagnosis of sepsis patients was significantly higher than the APACHEⅡ score, LAC and the predictive value of P(cv-a)CO₂(P < 0.05), the best cutoff value was >2.05 mmHg/mL with the combined diagnostic sensitivity of 72.93%, specificity of 82.64%.

ConclusionsP(cv-a)CO₂/C(a-cv)O₂ can effectively predict the risk of disease deterioration in patients with sepsis.