Study on the value of ¹⁸F-FDG PET-CT in the evaluation of the clinical and pathological features of invasive ductal carcinoma of breast

ObjectiveTo evaluate the relationship between the metabolic parameters of 18F-deoxyglucose positron emission computed tomography(¹⁸F-FDG PET-CT) and clinical and pathological characteristics of invasive ductal carcinoma of breast.

MethodsThe clinical data of 40 primary lesions of invasive ductal carcinoma of breast diagnosed by pathology and scanned by ¹⁸F-FDG PET-CT before operation were retrospectively analyzed.The max of standardized uptake value(SUVmax), mean of standardized uptake value(SUVmean) and metabolic tumor volume(MTV) of lesions were measured, and the total lesion glycolysis(TLG) of lesions were calculated.

ResultsThe SUVmax and MTV of the PR(-) group were higher than those of the PR(+) group.The SUVmax, SUVmean, TLG and MTV of the ER(-) group were higher than those of the ER(+) group.The MTV of the HER-2(-) group was lower than that of HER-2(+) group, the SUVmax, SUVmean, TLG and MTV of the stage T1-T2 tumors were less than those of the stage T1-T2 tumors, and the SUVmax, SUVmean, TLG and MTV in cases with axillary lymph node metastasis were higher than those in cases without axillary lymph node metastasis(P < 0.05 to P < 0.01).The SUVmax and MTV were positively correlated with the expression of Ki-67 in primary lesions(P < 0.01).The SUVmax of axillary lymph nodes was positively correlated with the expression of Ki-67 in the primary lesions(P < 0.01).

ConclusionsThe ¹⁸F-FDG PET-CT metabolic parameters can evaluate the biological and clinical characterstics of invasive ductal carcinoma of breast.