Clinical characteristics of reflux esophagitis with sleep disorder

ObjectiveTo investigate the clinical characteristics of reflux esophagitis (RE) patients with sleep disorder.

MethodsThe sleep status of 105 patients with RE diagnosed by gastroscopy was prospectively investigated.The RE patients were divided into sleep disorder group and normal sleep group according to the Pittsburgh sleep quality index (PSQI) score.The gastroesophageal reflux disease questionnaire (GERDQ), Hamilton anxiety scale (HAMA) and Hamilton depression scale(HAMD) were used to score the reflux symptoms, anxiety and depression status of all patients, respectively.The Los Angeles classification was used to grade all patients with endoscopic esophagitis.

ResultsThe symptom score, HAMA score and HAMD score of RE patients with sleep disorder were higher than those of RE patients without sleep disorder(P < 0.05 to P < 0.01).Furthermore, the PSQI score of patients with grade C/D esophagitis was showed to be significantly higher than that of patients with grade A/B esophagitis(P < 0.01).Finally, the GERDQ score of patients with RE was found to be positively correlated with PSQI score (r=0.482, P < 0.01).

ConclusionsThe clinical symptoms are more serious in RE patients with sleep disorder.Anxiety and depression are easy to be found, and the severity of esophagitis is showed to be related to sleep quality in this kind of disease.