Effect of the esketamine on postoperative analgesia, inflammatory factors and early mood in patients with breast cancer

ObjectiveTo investigate the effects of esketamine on the postoperative analgesia, inflammatory factors and early mood in patients with breast cancer.

MethodsA total of 90 patients scheduled by radical mastectomy were randomly divided into the observation group and control group(45 cases in each group).Two groups were treated with general anesthesia, and the patient-controlled intravenous analgesia pump with 2 μg/kg sufentanil, 0.5 mg/kg esketamine combined with 20 mg azasetron and 2 μg/kg sufentanil combined with 20 mg azasetron were implemented in the observation group and control group after operation, respectively.The visual analogue scale(VAS) score, Athens-insomnia scale(AIS) score, self-rating anxiety scale(SAS) score, self-rating depression scale(SDS) score, incidence rate of adverse reactions and serum levels of tumor necrosis factor-α(TNF-α) and interleukin-6 (IL-6) were compared between two groups.

ResultsThe VAS scores in observation group at T₁(after 6 h of operation), T₂(after 24 h of operation) and T₃(after 48 h of operation) time points were significantly lower those that in control group(P < 0.05 to P < 0.01).There was no statistical significance in the serum levels of TNF-α and IL-6 between two groups at T₀(before 24 h of operation)(P>0.05), and the levels of TNF-α and IL-6 in observation group were significantly lower than those in control group at T₁ and T₂(P < 0.05).The differences of the scores of AIS, SAS and SDS between two groups at T₀ were not statistically significant (P>0.05), and the scores of AIS, SAS and SDS in observation group at T₂ and T₃ were significantly lower than those in control group(P < 0.05 to P < 0.01).The incidence rate of postoperative analgesic rescue in observation group was significantly lower than that in control group(P < 0.05), and the incidence rate of swirl in observation group was significantly higher than that in control group(P < 0.05).

ConclusionsThe application of esketamine in postoperative analgesia of patients treated with radical mastectomy can enhance the postoperative analgesia effects, reduce the postoperative inflammatory reaction, significantly improve the quality of sleep, reduce the anxiety and depression, and improve the quality of rehabilitation of patients.