orrelation between blood lipid level and bone mineral density in postmenopausal women

ObjectiveTo study the correlation between bone mineral density (BMD) level and blood lipid level, body mass index (BMI), menopausal years in postmenopausal women.

MethodsA total of 141 postmenopausal women were selected as the research objects.All research objects were tested for BMD (including lumbar L_1-4, femoral neck and hip joint, some patients added forearm) in the BMD testing room.According to the results (T value as the standard), the research objects were divided into three groups: group A(osteoporosis, T ≤-2.5), group B(osteopenia, -2.5 < T < -1.0) and group C(normal bone mass, T ≥-1.0).Fasting blood from all subjects were collected to detect the levels of total cholesterol (TC), low density lipoprotein (LDL), triglycerides (TG) and high density lipoprotein (HDL).The height, weight, age, and menopause age of patients were recorded.The BMI and menopause years were calculated.

ResultsThe comparison results of LBMD, FBMD and TBMD in the three groups were group C>group B>group A (P < 0.05).There were significant differences in HDL, TG and TC levels among the three groups (P < 0.05 to P < 0.01), and the HDL level in group A was higher than that in group C (P < 0.05);TG levels in group A and group B were lower than those in group C (P < 0.01);TC level in group C was lower than that in group A(P < 0.05).There was no significant difference in LDL levels among the three groups(P>0.05).Correlation analysis showed that age and menopausal years were negatively correlated with BMD values in all parts (P < 0.05 to P < 0.01).Height, body weight and BMI were positively correlated with BMD in all parts (P < 0.05 to P < 0.01).TG level was positively correlated with LBMD, FBMD and TBMD (P < 0.01).TC level was negatively correlated with LBMD (P < 0.05 to P < 0.01).Multivariate logistic regression analysis showed that the risk of OP was lower in those with high BMI and TG, and higher in those with old age, long menopause and high TC.The ROC curve was drawn to analyze the value of TC in predicting OP in postmenopausal women, and the area under ROC curve was calculated to be 0.636 (P < 0.05).

ConclusionsThe correlation between different blood lipids and BMD in different parts of postmenopausal women is different.The increase of TC is related to the decrease of LBMD.Postmenopausal women with low BMI, old age, long menopause years and high TC are more prone to osteoporosis.