Correlation between the degree of coronary artery disease and MDA and SOD in patients with type 2 diabetes mellitus complicated with coronary heart disease

ObjectiveTo explore the characteristics of coronary artery lesions in patients with type 2 diabetes mellitus (T2DM) complicated with coronary heart disease (CHD), and to analyze the correlation between the number of coronary artery lesions and the level of oxidative stress.

MethodsA total of 198 patients who underwent coronary angiography were divided into two groups according to whether they had T2DM history: 65 patients in T2DM combined with CHD group and 133 patients in CHD group.The clinic-related indexes of the two groups were measured.The correlation between the number of different coronary artery lesions and malondialdehyde (MDA) and superoxide dismutase (SOD) was analyzed according to the results of coronary angiography.

ResultsThe level of MDA in the T2DM combined with CHD group was higher than that in the CHD group (P < 0.01), that and the level of SOD was lower than that in the CHD group (P < 0.05).The proportion of two or more coronary artery lesions in the T2DM group with CHD was higher than that in the CHD group(P < 0.01).In the T2DM combined with CHD group, the level of SOD in the group with one coronary artery lesion was higher than that in the group with two or more coronary artery lesions, and the level of MDA was lower than that in the group with two or more coronary artery lesions (P < 0.01).

ConclusionsThe oxidative stress level of T2DM patients with CHD is higher than that of CHD alone, and the coronary artery disease is more severe.The oxidative stress level increases with the aggravation of the number of coronary artery lesions.