Expression and significance of serum homocysteine and 25(OH)D in patients with diabetic peripheral neuropathy and depression

ObjectiveTo explore the expression and significance of serum homocysteine (Hcy) and 25 hydroxy vitamin D 25(OH)D in patients with diabetic peripheral neuropathy (DPN) and depression.

MethodsThe clinical data of 80 patients with DPN and depression were retrospectively analyzed, and they were taken as DPN with depression group, and 60 DPN patients without depression were selected as DPN group, another 50 people undergoing health checkup during the same period were selected as control group.According to the Hamilton depression scale (HAMD) score, 80 patients with DPN and depression were divided into mild depression (32 cases), moderate depression (27 cases) and severe depression (21 cases).The expression levels of Hcy and 25(OH)D in different groups of patients were compared.The correlation between Hcy and 25(OH)D levels and whether DPN was associated with depressive symptoms was analyzed by Pearson correlation.

ResultsThe level of Hcy in the DPN with depression group was significantly higher than that in the DPN group and the control group, and the level of 25(OH)D was significantly lower than that in the DPN group and the control group; the level of Hcy in the DPN group was significantly higher than that in the control group, and the level of 25(OH)D was significantly lower than that in the control group (P < 0.01).The Hcy level in the severe depression group was significantly higher than that in the moderate and mild depression groups, and the 25(OH)D level was significantly lower than that in the moderate and mild depression groups; the Hcy level in the moderate depression group was significantly higher than that in the mild depression group, and the level of 25(OH)D was lower than that in the mild depression group (P < 0.05 to P < 0.01).The Pearson correlation analysis showed that the level of Hcy was significantly positively correlated with whether DPN was associated with depressive symptoms (P < 0.01), and the level of 25(OH)D was significantly negatively correlated with whether DPN was associated with depressive symptoms (P < 0.01).

ConclusionsThe increase of Hcy level and the decrease of 25(OH)D level are related to the occurrence of DPN with depressive symptoms and the severity of depression, which should be paid attention to in clinic.