Effects of closed-loop target controlled infusion and continuous infusion of cis-atracurium on MAP, HR, SpO₂ and muscle relaxant dosage in patients undergoing cholecystectomy

ObjectiveTo explore the effects of closed-loop target controlled infusion and continuous infusion of cis-atracurium on mean arterial pressure (MAP), heart rate (HR), blood oxygen saturation (SpO₂) and muscle relaxant dosage in patients undergoing cholecystectomy.

MethodsNinety patients with cholecystectomy were divided into the control group (n=45) and observation group (n=45) by lot.The control group was continuously infused with cis-atracurium, and the observation group was infused with cis-atracurium by closed-loop target controlled infusion.MAP, HR, SpO₂, ETCO₂, muscle relaxation state, postoperative recovery state and incidence of complication before induction (T₁), 5 minutes after intubation (T₂), 1 minute before extubation (T₃), 2 minutes after extubation (T₄), 24 hours after extubation (T₅) were compared between the two groups.

ResultsThe comparison of MAP and HR levels of patients in the same group at different time points showed that compared with T₁, the levels of MAP and HR decreased significantly at T₂ (P < 0.01), increased at T₃ (P < 0.01), and then gradually recovered to the levels at T₁ (P>0.05);the comparison between groups showed that there was no significant difference in the levels of the two indicators at different time points (P>0.05).The comparison of SpO₂ and ETCO₂ levels of patients in the same group at different time points showed that there was no significant change at each time point (P>0.05);the comparison between groups showed that only at T₂ time point, the ETCO₂ level of patients in the observation group was slightly higher than that in the control group (P < 0.05), and there was no significant difference in SpO₂ and ETCO₂ levels between the two groups at other time points (P>0.05).The onset time, duration time and recovery time of muscle relaxant in the observation group were shorter than those in the control group (P < 0.01), and there was no significant difference in the extubation time between the two groups (P>0.05).

ConclusionsBoth closed-loop target controlled infusion and continuous infusion of cis-atracurium have good effects on cholecystectomy, but the former has less muscle relaxant dosage and is more effective.