Analysis of the efficacy of single stent thrombectomy and intravenous thrombolytic bridging stent thrombectomy in the treatment of intracranial large vessel occlusion

ObjectiveTo compare the efficacy and safety between single stent thrombectomy and intravenous thrombolytic bridging stent thrombectomy in the treatment of intracranial large vessel occlusion.

MethodsThe clinical data of 48 patients with acute intracranial large vessel occlusion within 6 h were retrospectively analyzed, and the patients were divided into the stent thrombectomy group and bridge treatment group.The baseline data were compared between two groups.After two groups were treated for 14 d, the efficacy of two groups were analyzed using the National Institutes of Health stroke scale(NIHSS).The prognosis, adverse reactions and death of modified Rankin score(mRS) in two groups at 90 d of treatment were observed.

ResultsThe results of comparison of the 14-day effective rate between two groups showed that the cumulative effective rate in two groups were high(77.78% and 85.71%), and the difference of which was not statistically significant(P>0.05).The total proportion of cured and effective rate in bridge treatment group after 14 d of treatment was higher than that in stent thrombolysis group(P < 0.05).The differences of the time from admission to vascular recanalization, times of thrombectomy, prognosis, symptomatic intracranial hemorrhage and one-month all-cause mortality between two groups were not statistically significant(P>0.05), and the good prognosis rate of 90 d in bridging group was higher than that in stent thrombectomy group(P < 0.05).

ConclusionsBoth simple stent thrombectomy and intravenous thrombolysis bridging stent thrombectomy can rapidly open the intracranial occluded aorta, and the bridging group has better short-term and long-term efficacy.