Value of serum Cr, hs-CRP, Cys-C and SOD levels in differential diagnosis of patients with acute and chronic renal failure

ObjectiveTo analyze the value of serum creatinine(Cr), hypersensitive C-reactive protein(hs-CRP), cystatin C(Cys-C), and superoxide dismutase(SOD) levels in the differential diagnosis of patients with acute and chronic renal failure.

MethodsA total of 83 patients with renal failure were selected as research objects, and 101 healthy subjects were selected as control group in the same period.The levels of serum Cr, hs-CRP, Cys-C and SOD were detected.The ROC curve was drawn, and the value of each index in predicting acute and chronic renal failure was analyzed.

ResultsThe levels of Cr, hs-CRP and Cys-C in 83 patients with renal failure were significantly higher than those in the control group(P < 0.01), and the level of SOD was significantly lower than that in the control group(P < 0.01).The levels of serum Cr, hs-CRP and Cys-C in patients with acute renal failure were significantly lower than those in patients with chronic renal failure(P < 0.01), and the level of SOD was significantly higher than that in patients with chronic renal failure(P < 0.05).The AUC of Cr and Cys-C in the differential diagnosis of acute and chronic renal failure was 0.73 and 0.82, respectively, the difference of which was statistically significan(P < 0.01).The AUC of hs-CRP and SOD in differential diagnosis of acute and chronic renal failure was 0.40 and 0.38, respectively, the difference of which was not statistically significance(P>0.05).

ConclusionsThe value of serum Cr and Cys-C levels in differential diagnosis of acute and chronic renal failure was significantly better than that of hs-CRP and SOD levels.