Levels and clinical significance of sCD28 and sCD137 in peripheral blood of SLE patients

ObjectiveTo investigate the correlation of the serum levels of sCD28 and sCD137 in systemic lupus erythematosus(SLE) and its significance.

MethodsThe serum sCD28 and sCD137 in 54 patients with SLE and in healthy control were detected by BA-ELISA.The correlation of the serum levels of sCD28 and sCD137 with the SLE patients'disease activity index(SLEDAI) score and laboratory findings were analyzed.

ResultsThe levels of serum sCD28 and sCD137 in SLE were significantly higher than those in healthy control group(P < 0.01).The levels of serum sCD28 and sCD137 in active SLE were significantly higher than those in remission(P < 0.01).The levels of serum sCD28 and sCD137 in SLE were positively correlated with SLEDAI score and antinuclear antibaby, but were negatively correlated with complement C3(P < 0.01).

ConclusionsThere was positive correlation between the levels of serum sCD28 and sCD137 in SLE and its diseases activity index, which is expected to be one of the reference indexes to judge SLE disease activity.