Observation on the curative effect of Shengmai Dihuang Decoction combined with retention enema of traditional Chinese medicine on treating stage Ⅲ- Ⅳ patients with diabetic nephropathy

ObjectiveTo investigate the curative effect of Shengmai Dihuang Decoction combined with retention enema therapy of traditional Chinese medicine on the treatment of patients with diabetic nephropathy(DN) stage Ⅲ-Ⅳ, the renal vascular endothelial function, the serum tissue inhibitor of matrix metalloproteinase-1(TIMP-1) and transforming growth factor-β1(TGF-β1).

MethodsA total of 100 patients with stage Ⅲ-Ⅳ DN were selected as the research objects, and they were randomly divided into 3 groups, with 34 cases in the observation group, 33 cases in the control group A, and 33 cases in the control group B.ALL groups were treated with conventional Western medicine.On this basis, the control group A was treated with Shengmai Dihuang Decoction, the control group B was treated with traditional Chinese medicine retention enema therapy, and the observation group was treated with Shengmai Dihuang Decoction combined with traditional Chinese medicine retention enema therapy.The clinical efficacy, TCM syndrome scores before and after treatment, blood glucose indicators fasting blood glucose(FBG), 2 h postprandial blood glucose(2hPG), glycosylated hemoglobin(HbAlc), renal function indicators serum creatinine(SCr), urea nitrogen(BUN), 24-hour urinary protein excretion rate(UAER), renal vascular endothelial function indexes endothelin-1(ET-1), soluble intercellular adhesion molecule-1(sICAM-1), arterial blood flow media Guided endothelium-dependent relaxation function(FMD), serum TIMP-1, TGF-β1 levels were observed and compared in the three groups.

ResultsThe total effective rate of treatment in the observation group was 97.06%, which was higher than the control group A(75.76%), and the control group B 69.70%(P < 0.05);after 1 and 3 months of treatment, the observation group's TCM syndrome score was lower than that in the control group A and B(P < 0.05).After 1, 3 months of treatment, FBG, 2hPG, HbAlc, BUN, UER, SCr, ET-1, sICAM-1, FMD, TIMP-1, TGF-β1 levels: observation group < control group A < Control group B(P < 0.05).

ConclusionsThe treatment of patients with DNⅢ-Ⅳ stage of Shengmai Dihuang Decoction combined with traditional Chinese medicine retention enema therapy can significantly improve the symptoms and signs of patients, reduce blood glucose levels, promote the recovery of renal function and renal vascular endothelial function, and regulate serum TIMP-1 and TGF-β1 level, which further improves the clinical treatment effect.