ObjectiveTo explore the laboratory examination and analysis of Kawasaki disease(KD) complicated with Mycoplasma pneumoniae infection and the risk factors of coronary artery disease.
MethodsNinety-two children with KD were divided into the observation group and control group according to their Mycoplasma pneumoniae infection.Blood C reactive protein (CRP), erythrocyte sedimentation rate (ESR), aspartate aminotransferase (AST), creatine kinase isoenzyme (CK-MB), procalcitonin (PCT), hemoglobin (HB), serum immunoglobulin (Ig) and complement were detected and analyzed.According to the presence or absence of coronary artery disease, the children were divided into the coronary artery disease group and non coronary artery disease group, and the relevant factors were selected for logistic regression analysis.
ResultsAmong 92 children with KD, 48 cases(52.2%) were complicated with Mycoplasma pneumoniae infection.CRP, ESR, PCT, IgG and C3 in the observation group were higher than those in the control group(P<0.05 to P<0.01).Sex, fever time, Hb, ESR, Mycoplasma pneumoniae infection and non response to γ-globulin were closely related to coronary artery disease in children with KD (P<0.05 to P<0.01).Multivariate logistic regression analysis showed that the independent risk factors of KD children complicated with coronary artery disease were fever time≥7 d (OR=3.229, P<0.01), Hb<100 g/L(OR=2.114, P<0.05), Mycoplasma pneumoniae infection(OR=3.356, P<0.01), and no response to γ-globulin (OR=3.655, P<0.01).
ConclusionsMycoplasma pneumoniae infection may be one of the causes of KD.There was a positive correlation between KD complicated with Mycoplasma pneumoniae infection and CRP, ESR, PCT, IgG and C3 in patients with KD.Fever time≥7 d, Hb<100 g/L, Mycoplasma pneumoniae infection and non response to γ-gamma globulin are the high-risk factors of KD children complicated with coronary artery disease.The intervention of these factors should be strengthened.
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