Analysis of cervical lesion characteristics in female patients with HPV multiple-infection

ObjectiveTo investigate the distribution of cervical lesions in female patients with HPV multiple infection and the association between HPV multiple-infection and cervical lesions.

MethodsA total of 6 382 individuals ranging in 19-90 years old from Huaibei Miners General Hospital from March 2017 to March 2019 were recruited.Cervical scrapings were examined by cytopathology and colposcopy-directed biopsies.HPV genotyping was performed by using PCR-reverse dot blotting system.The data of the distribution and subtypes of cervical lesions among HPV multiple-infection at different age groups were analyzed using Spss19.0.

ResultsThe HPV positive rate of 6 382 patients was 16.36%(1 044/6 832), including 344 cases with multiple subtypes of HPV infection.In addition, the HPV multiple-infection rate was 5.4%.The top three high-risk subtypes prevalence of HPV multiple-infection were HPV52, HPV16 and HPV58.The distribution of HPV multiple-infection of LSIL and HSIL were mainly in the 41-50 age group, while cervical cancer mainly distributed in the 51-60 age group.HPV multiple mixed-infections were mainly high-risk HPV coinfections, followed by high-risk and low-risk coinfections, and the low-risk coinfections.The difference of cervical lesions between high-risk HPV coinfections and high-risk and low-risk coinfections was statistically significant(P<0.01).However, the incidence rate between high-risk HPV coinfections and low-risk coinfections was not statistically significant(P>0.05).

ConclusionsThe pathogenicity of HPV multiple-infection genotype(high-risk coinfection) is associated with cervical lesions(except cervical cancer).The females from 41 to 60 years old is the high-risk age for cervical lesions and cervical cancer.