ObjectiveTo investigate the correlation of serum human epididymal protein 4 (HE4), Cystatin C and brain natriuretic peptide (BNP) with the severity and prognosis of heart failure in patients with chronic heart failure.
MethodsA total of 120 patients with chronic heart failure were collected as subjects.According to the NYHA classification standard, patients were divided into 24 cases of class Ⅱ, 53 cases of class Ⅲ and 43 cases of class Ⅳ.The patients were further divided into death group(n=31) and survival group(n=89) according to the death.Seventy-five healthy patients were randomly selected as the control group at the same time.Serum levels of HE4, Cystatin C and BNP in each group were determined by enzyme-linked immunosorbent assay.
ResultsSerum HE4, Cystatin C and BNP level in class Ⅳ patients were the highest, followed by class Ⅲ and Ⅱ, control group was the lowest (P<0.01).Compared with the control group, serum HE4, Cystatin C and BNP levels in the control group were significantly increased, and LVEF was significantly decreased (P<0.01).Serum HE4, Cystatin C and BNP were the major risk factors for poor prognosis (OR=1.999, 2.333, 1.809, P<0.01), while LVEF was the protective factor (OR=0.734, P<0.01).The predictive value of serum HE4, Cystatin C and BNP combined with LVEF was higher than those of each individual test.
ConclusionsElevated serum HE4, Cystatin C and BNP levels are closely related to the severity and prognosis of patients with chronic heart failure.The combination of three indicators and LVEF test is helpful to predict the risk of poor prognosis, which has certain clinical value in the diagnosis and treatment of chronic heart failure.
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