Expression and significance of polymeric immunoglobulin receptor regulated by miR-5585-5p in breast cancer

ObjectiveTo investigate the expression of polymeric immunoglobulin receptor (pIgR) regulated by microRNA (miR)-5585-5p and the differential expression of pIgR in breast cancer tissue (BRCA) and non-cancer tissues (NCT).

MethodsBioinformatics method was used to analyze the regulatory effect of miR-5585-5p on pIgR, the expression of pIgR in breast cancer and its effect on survival and prognosis of patients.Fluorescence quantitative PCR was used to detect the regulatory effect of miR-5585-5p on pIgR.Immunohistochemical method was used to detect the expression of pIgR in tumor tissues of breast invasive ductal carcinoma patients and normal breast tissues of non-cancer patients, and to analyze the relationship between the expression of pIgR and the clinicopathological characteristics of patients in BRCR group.

ResultsmiR-5585-5p down-regulated the expression of pIgR (P < 0.01).Bioinformatics analysis showed that the expression of pIgR was low in breast cancer patients (P < 0.01).Immunohistochemical results showed that there were significant differences in the expression of pIgR among patients with different histological grades, lymph node metastasis numbers and HER-2, ER expression (P < 0.05 to P < 0.01).

ConclusionsmiR-5585-5p targets to regulate the expression of pIgR and is associated with the prognosis of breast cancer patients, suggesting that it may be used as a biomarker to help molecular typing, prognosis judgment and treatment scheme selection of breast cancer.