Study on the correlation between the degree of simple obesity and expression levels of BNP, IGF-1 and 25-(OH)D3 in children

ObjectiveTo explore the correlation between the simple obesity and levels of brain natriuretic peptide(BNP), insulin-like growth factor 1(IGF-1) and 25-hydroxy vitamin D325-(OH)D3 in children.

MethodsOne hundred children with simple obesity followed up in department of pediatrics were divided into the mild and moderate obesity group(50 cases) and severe obesity group(50 cases).Meanwhile, 50 healthy children with normal weight of physical examination were set as the control group.The serum levels of BNP, IGF-1 and 25-(OH)D3 in three groups were determined using radioimmunoassay and ELISA, the diagnostic value of which in simple obesity was identified, and their correlation were analyzed.

ResultsThe difference of the serum level of BNP between the mild and moderate obesity group and severe obesity group was not statistically significant(P>0.05), and the serum levels of BNP in mild and moderate obesity group and severe obesity group were higher than that in control group(P < 0.01).The serum levels of IGF-1 in obesity group were higher than that in control group(P < 0.01), and which increased with the increasing of the degree of obesity(P < 0.01).The serum levels of 25-(OH)D3 in obesity group were lower than that in control group(P < 0.01), and which decreased with the increasing of the degree of obesity(P < 0.05).The area under the diagnostic curve of serum 25-(OH)D3, IGF-1 and BNP was 0.872, 0.816 and 0.685, respectively.The sensitivities of serum BNP, IGF-1 and 25-(OH)D3 to simple obesity were 55.24%, 62.56%, 78.36%, respectively, and the specificities of serum BNP, IGF-1 and 25-(OH)D3 to simple obesity were 67.21%, 78.28%, 82.38%, respectively.The results of correlation analysis showed that the serum level of 25-(OH)D3 was negatively correlated with the degree of simple obesity(r=-0.614, P < 0.05), and the serum levels of IGF-1 and BNP were positively correlated with simple obesity in children(r=0.427, 0.244, P < 0.05).

ConclusionsThe serum levels of BNP, IGF-1 and 25-(OH)D3 are closely correlated with the degree of simple obesity.