Effect of elevated cholesterol and triglyceride levels on frequency of gout attacks

ObjectiveTo investigate the effect of elevated blood lipid levels on the frequency of gout attacks.

MethodsA total of 158 gout patients were selected and divided into normal cholesterol and triglyceride group (group A, n=56), simple elevated cholesterol group (group B, n=21), simple elevated triglyceride group (group C, n=50) and elevated cholesterol and triglyceride group (group D, n=31) according to the blood lipid levels. A cohort study was conducted to compare the frequency of gout attacks in patients with different blood lipid levels.

ResultsCompared with the group A, the frequency of gout attacks in the group B, group C and group D increased at 1, 3, 6 and 12 months (P < 0.05), and with the extension of time, the frequency of gout attacks in the four groups increased at different time periods (P < 0.05). The patients were paired according to age, body mass index, course of disease, uric acid and blood glucose level, and the results showed that group A and group B were paired with 14 pairs, which were recorded as group A1 and group B1, the frequency of gout attacks in the group B1 was significantly higher than that in the group A1 within 3, 6 and 12 months (P < 0.01);group A and group C were paired with 28 pairs, which were recorded as group A2 and group C2, the frequency of gout attacks in the group C2 was higher than that in the group A2 within 3, 6 and 12 months (P < 0.05 to P < 0.01);group A and group D were paired with 13 pairs, which were recorded as group A3 and group D3, the frequency of gout attacks in the group D3 was significantly higher than that in the group A3 within 3, 6 and 12 months (P < 0.01).

ConclusionsElevated blood lipid level can increase the frequency of gout attacks.