Predictive analysis of different biochemical indicators in the assessment of severe acute pancreatitis complicated with infection

ObjectiveTo explore the clinical application value of neutrophil-lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), white blood cell (WBC), blood amylase (AMS), urinary amylase (UAMY), heparin binding protein(HBP) and procalcitonin(PCT) in the evaluation of infection and severity of disease in patients with severe acute pancreatitis, and explore the infection markers with good specificity and sensitivity.

MethodsThe clinical data of 64 patients with severe acute pancreatitis were retrospectively analyzed. According to the incidence of co-infection, the 64 patients were divided into the infection group (34 cases) and the non-infection group (30 cases). On admission, venous blood was collected to detect NLR, PLR, WBC, AMS, HBP and PCT. Urine samples were collected to detect UAMY, and the data were analyzed.

ResultsThere were significant differences in the levels of WBC, NLR, PLR, HBP and PCT between the non-infection group and the infection group (P < 0.01). There was no significant difference in AMS and UAMY levels between the two groups (P>0.05). AMS and UAMY had no statistical significance in the diagnosis of acute pancreatitis complicated with infection (P>0.05). WBC, NLR, PLR, HBP and PCT had the statistical significance in the diagnosis of severe acute pancreatitis with sensitivity(PLR>PCT>NLR>HBP>WBC), specificity(PCT>NLR>PLR>HBP>WBC) and area under ROC curve (AUC)(PCT>HBP>PLR>NLR>WBC) (P < 0.05).

ConclusionsThe monitoring of NLR, PLR, WBC, HBP and PCT has the important clinical value for the early prediction of severe acute pancreatitis complicated with infection, which is helpful to judge the condition and guide the follow-up treatment.