Effect of Wenxin granule combined with nicorandil on the ventricular arrhythmia in STEMI patients after emergency PCI

ObjectiveTo investigate the effects of Wenxin granule combined with nicorandil on ventricular arrhythmia in ST segment elevation myocardial infarction(STEMI) patients after emergency percutaneous coronary intervention(PCI).

MethodsOne hundred and twenty STEMI patients treated with emergency PCI were randomly divided into the control group, Wenxin granule group, nicorandil group and combination group(30 cases in each group).The incidence rates of ventricular arrhythmia were compared among the four groups after 3 days of operation, and the QT interval dispersion(QTd) and corrected QT interval dispersion(QTcd) in fours groups before operation, after 6, 24, 48 and 72 h of operation were analyzed.

ResultsThe incidence rates of ventricular premature systole and unsustainable ventricular tachycardia/ventricular fibrillation in combination group, Wenxin granule group and nicorandil group were significantly lower than those in control group(P < 0.05).The incidence rates of ventricular premature systole and unsustainable ventricular tachycardia/ventricular fibrillation in combination group were significantly lower than that in Wenxin granule group and nicorandil group(P < 0.05).The differences of the preoperative QTd and QTcd among four groups were not statistically significant(P>0.05).The QTd and QTcd in combination group after 6, 24, 48 and 72 h of operation were significantly lower than those in control group, Wenxin granule group and nicorandil group(P < 0.01).

ConclusionsThe Wenxin granule combined with nicorandil can effectively reduce the incidence rate of ventricular arrhythmia in STEMI patients treated with emergency PCI, and shorten QTd and QTcd.