Effect of uterine manipulator on the positive rate of vascular tumor thrombus in laparoscopic radical cervical cancer surgery based on propensity score matching

ObjectiveTo investigate the effect of uterine manipulator on the positive rate of vascular tumor thrombus in laparoscopic radical hysterectomy for cervical cancer.

MethodsThe clinical data of patients with cervical cancer who underwent laparoscopic radical hysterectomy in our hospital from November 2018 to March 2021 were included.After the screening by inclusion and exclusion criteria, 109 effective patients were included, including 73 cases in the uterine manipulator group and 36 cases in the non-uterine manipulator group.Using propensity score matching as 1:1, the difference was balanced between patient groups.Immunohistochemical method was used to detect the CD34 labeled microvessel density (MVD), D2-40 labeled microlymphatic vessel density (MLVD) and the positive rate of vascular tumor thrombus.The effects of the two surgical methods on the positive rate of vascular tumor thrombus were analyzed.

ResultsAfter propensity score matching, 23 patients were included in each group.There was no significant difference in vessel count and positive rate of vessel tumor thrombus in cancer tissues and adjacent tissues between the two groups (P>0.05).

ConclusionsIn laparoscopic radical hysterectomy for cervical cancer, whether or not to use a uterine manipulator during the operation has no effect on the positive rate of vessels in cancer and adjacent tissues, and it is safe and feasible to use a uterine manipulator.