Prognostic value of NLR and PLR in patients with locally advanced cervical cancer undergoing definitive chemoradiotherapy

ObjectiveTo analyze the prognostic significance of peripheral blood neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in patients with cervical cancer receiving definitive chemoradiotherapy.

MethodsOne hundred and twenty-five patients with locally advanced cervical cancer who received definitive chemoradiotherapy were analyzed retrospectively.NLR and PLR were calculated after external irradiation (before internal irradiation), and the correlation of NLR and PLR with survival, recurrence, and clinical factors were analyzed.

ResultsAfter external irradiation, the median values of NLR and PLR were 2.62 and 114, respectively, and NLR=2.62 and PLR=114 were selected as cut-off values.By means of univariate and multivariate analysis, the results showed that the International Federation of Gynaecology and Obstetrics and Obstetrics staging, NLR, and PLR were independent risk factors for overall survival and disease-free survival in patients with cervical squamous cell carcinoma after external irradiation (P < 0.01 and P < 0.05)

ConclusionsThe inflammatory markers including NLR and PLR can be a new method for monitoring the treatment response and prognosis of definitive chemoradiotherapy patients.