Analysis of cervical HPV genotypes in 6 494 gynecological outpatients

ObjectiveTo analyze the distribution characteristics of cervical human papillomavirus(HPV) genotypes in gynecological outpatients in Nanjing, so as to provide support for the prevention and treatment of cervical cancer.

MethodsThe data of 6 494 patients with HPV genotype detected by cervical exfoliated cells in gynecological clinic were analyzed by collecting data from hospital information system.

ResultsA total of 1 882 of 6 494 patients were positive for HPV infection, and the positive rate was 28.98%.There was significant difference in the positive rate of HPV infection among different age groups(P < 0.01).The positive rate of HPV infection in the group ≤ 19 years old was 74.70%(62/83), which was higher than that in other age groups(P < 0.05).The main patients were single HPV infection(1 199/6 494, 18.46%).There was no significant difference in the rate of single HPV infection among patients of different ages(P>0.05), but there was significant difference in the rate of double and multiple HPV infection(P < 0.01).The infection rate of high-risk HPV was the main type of patients(21.96%, 1 426/6 494).Among the 24 genotypes of HPV, the top five overall infection rates were HPV52, HPV16, HPV58, HPV51 and HPV42.There was no significant difference in HPV35 infection rate among different age groups(P>0.05), but the infection rate of other HPV genotypes had statistical significance among different age groups(P < 0.05 to P < 0.01).

ConclusionsBy clarifying the genotype distribution characteristics of HPV infection in local outpatients, it can provide a certain reference basis for the treatment and prevention of cervical cancer.