ERP characteristics and source analysis of non-organic insomnia based on P300

ObjectiveTo explore the P300 characteristics and source analysis of non-organic insomnia at event-related potential.

MethodsThe subjects were divided into healthy control group (n=10) and non-organic insomnia group (n=10).The task state electroencephalogram and behavioral data of the subjects were recorded with EGI high-density electroencephalogram equipment, and the task state electroencephalogram was selected for the digital N-back task.The event-related potential was analyzed through Net Station software to extract P300 latency, amplitude and behavioral data from the Fz, Cz and Pz electrode points, and to to locate the source in the GeoSource toolbar.The source characteristics was compared between the two groups.

ResultsThe total score of Pittsburgh sleep quality index and its components, Hamilton anxiety scale score, Hamilton depression scale score in the non-organic insomnia group were higher than those in the healthy control group (P < 0.05 to P < 0.01).There was no significant difference in the accuracy and reaction time between the two groups in the 0-back and 1-back tasks (P>0.05), and there was significant difference in the accuracy and reaction time between the two groups in the 2-back task (P < 0.05).The P300 amplitude of Fz point in 0-back task and Fz point in 1-back task in non-organic insomnia group was lower than that in healthy control group (P < 0.05 and P < 0.01).The P300 latency of Fz, Cz, Pz points in the 2-back task in the non-organic insomnia group was longer than that in the healthy control group (P < 0.05).The source brain regions of task state were mainly concentrated in the frontal lobe.The active regions in the non-organic insomnia group were scattered, and the current intensity of the active regions in 0-back and 2-back was significantly lower than that in the healthy control group (P < 0.01).

ConclusionsSubjects with non-organic insomnia have slightly impaired working memory of brain, which distracts the cognitive resources of brain and reduces higher cognitive abilities such as brain execution.Therefore, the characteristics of event-related potential based on P300 and source analysis can be objectively assessed under certain conditions, and the convenience of which warrants future clinical promotion.