ObjectiveTo investigate the relationship between the expression levels of interleukin-1β(IL-1β), calpain-2(Calpain-2) and cardiac remodeling in patients with atrial fibrillation.
MethodsA total of 150 patients diagnosed with atrial fibrillation(AF) were selected as the observation group, and divided into non-paroxysmal AF group and paroxysmal AF group according to the 2020 ESC/EACTS GUIDELINES for the diagnosis and Management of AF.A total of 120 healthy subjects at the same period were selected as the control group.Serum IL-1β, Calpain-2 contents, left ventricular diastolic diameter(LVDd), left atrial diameter(LAD), left ventricular ejection fraction(LVEF) and left ventricular shortening fraction(FS) were detected by echocardiography, and the differences among the three groups were compared.Pearson correlation was used to analyze the correlation between serum IL-1β and Calpain-2 contents and the results of echocardiography.Binary logistic regression was used to explore the risk factors of AF.
ResultsThe contents of serum IL-1β and Calpain-2 in the observation group were significantly higher than those in the control group(P < 0.05), and those in the patients without paroxysmal AF were significantly higher than those in the patients with paroxysmal AF(P < 0.05).The indexes of LAD and LVDd in non-paroxysmal AF group were higher than those in paroxysmal AF group and control group(P < 0.05), but LVEF and FS were lower than those in paroxysmal AF group and control group(P < 0.05).Spearman correlation analysis showed that IL-1β and Calpain-2 were positively correlated with LAD and LVDd(P < 0.01), but negatively correlated with LVEF and FS(P < 0.01).Binary logistic regression analysis showed that IL-1β and Calpain-2 were the risk factors for AF.
ConclusionsIL-1β and Calpain-2 were positively correlated with LAD and LVDd, and were involved in the process of cardiac remodeling, thus promoting the occurrence and development of atrial fibrillation.
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