Effect of the continuous stellate ganglion block on the prevention of cerebral vasospasm after intracranial aneurysm intervention, and plasma levels of melatonin and endothelin-1

ObjectiveTo investigate the effects of continuous stellate ganglion block(SGB) on the prevention of cerebral vasospasm during intracranial aneurysm intervention, and levels of plasma melatonin(MT) and endothelin-1(ET-1).

MethodsEighty patients treated with intracranial aneurysm intervention were randomly divided into the observation group and control group according to the random number table method.The control group was treated with general anesthesia, and the observation group was additionally treated with continuous SGB on the basis of the control group.The anterior cerebral artery average blood flow velocity(ACA-Vm), anterior cerebral artery pulse index(ACA-PI), middle cerebral artery average blood velocity(MCA-Vm), middle cerebral artery pulsation index(MCA-PI), MT and ET-1 levels and postoperative 24 h complications were compared between two groups.

ResultsThe ACA-Vm, ACA-PI, MCA-Vm, MCA-PI, PCA-Vm and PCA-PI in control group were significantly higher than those in observation group after treatment(P < 0.05 to P < 0.01).After treatment, the levels of MT and ET-1 in control group were significantly lower and higher than those in observation group(P < 0.05).After 24 h of operation, the incidence rate of complication in control group(22.50%) was significantly higher than that in observation group(7.50%)(P < 0.05).

ConclusionsThe continuous SGB can effectively stabilize the cerebral blood flow after intracranial aneurysm intervention, promote the secretion and synthesis of MT, and inhibit the increasing of ET-1 level, so as to reduce the incidence rate of complications such as cerebral vasospasm.