Effect of standard quadruple combined with Jinghua Weikang capsule on the levels of serum gastrin 17 and PG, and immune function in chronic atrophic gastritis patients with positive Hp

ObjectiveTo analyze the effects of standard quadruple combined with Jinghua Weikang capsule on the levels of serum gastrin 17(G-17) and pepsinogen(PG), and immune function in chronic atrophic gastritis patients with positive Hp.

MethodsOne hundred and twenty chronic atrophic gastritis patients with positive Hp were divided into the observation group and control group according to the random number table method(60 cases in each group).The standard quadruple therapy in the control group were given, and the Jinghua Weikang capsule treatment in the observation group were additionally given on the basis of the control group.The clinical efficacy, eradication rate of Hp, serum levels of G-17, PGⅠ, PGⅡ, CD4⁺, CD8⁺, CD4⁺/CD8⁺ before and after treatment, and incidence rate of adverse reactions were compared between two groups.

ResultsThe total clinical effective rate and clearance rate of Hp in the observation group were 93.33% and 96.67%, respectively, which were significantly higher than those in control group(75.00% and 81.67%)(P < 0.01).After treatment, the serum levels of G-17 and PGⅠ significantly increased, while the level of PG Ⅱ significantly decreased in two groups; the serum levels of G-17 and PGⅠ in observation group were significantly higher than those in control group, and the PG Ⅱ level in observation group was significantly lower than that in control group(P < 0.05 to P < 0.01).After treatment, the levels of CD4⁺ and CD4⁺/CD8⁺ significantly increased, and the CD8⁺ level significantly decreased in two groups; the levels of CD4⁺, CD8⁺ and CD4⁺/CD8⁺ in observation group were significantly better than those in control group(P < 0.05 to P < 0.01).There was no statistical significance in the incidence rate of adverse reactions between two groups(P>0.05).

ConclusionsThe standard quadruple combined with Jinghua Weikang capsule can effectively improve the serum levels of G-17, PG and immune function in chronic atrophic gastritis patients with positive Hp, clearance rate of Hp and clinical total effective rate, which is worthy of clinical application.