ObjectiveTo explore the correlation between plasma D-dimer (D-D), fibrinogen (Fg) levels and left atrial dimension in patients with coronary heart disease and atrial fibrillation.
MethodsA total of 332 patients were enrolled and divided into coronary heart disease group(n=119), coronary heart disease atrial fibrillation group(n=108) and healthy group(n=105) according to the diseases suffered.Plasma D-D, Fg levels and left atrial dimension were measured and compared of all patients, Pearson method was used to analyze the correlation between the plasma D-D, Fg levels and left atrial dimension.
ResultsThe plasma D-D, Fg levels and left atrial end systolic diameter (LAD) in coronary heart disease group and coronary heart disease atrial fibrillation group were higher than those in healthy group, and those in coronary heart disease atrial fibrillation group were higher than those in coronary heart disease group(P < 0.01).The plasma D-D, Fg levels and LAD in acute myocardial infarction were higher than those in coronary heart disease angina pectoris and ischemic cardiomyopathy, and those of angina pectoris of coronary heart disease were higher than ischemic cardiomyopathy(P < 0.01).The plasma levels of D-D, Fg and LAD in permanent atrial fibrillation were higher than those in paroxysmal and persistent atrial fibrillation, and the plasma levels of D-D, Fg and LAD in persistent atrial fibrillation were higher than those in paroxysmal atrial fibrillation (P < 0.01).The plasma D-D and Fg levels were positively correlated with LAD in patients with coronary heart disease and atrial fibrillation (r=0.603, 0.612, P < 0.05 and P < 0.01).
ConclusionsThe plasma D-D and Fg levels in patients with coronary heart disease and atrial fibrillation are increased, which are positively correlated with left atrial dimension.
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