Analysis of the risk factors for recurrence after coning in patients with high-grade cervical intraepithelial neoplasia

ObjectiveTo investigate the high risk factors for recurrence of high-grade cervical intraepithelial neoplasia(CIN) patients after cervical conization.

MethodsThe clinical data of 145 patients with high-grade CIN were retrospectively analyzed.According to the recurrence situation within 2 years after operation, the patients were divided into the recurrence group and non-recurrence group.The age, pregnancy and delivery times, menopause, gland involvement, CIN grading and preoperative and postoperative HPV infection bewteen tewo groups were compared.The univariate analysis and multivariate logistic regression were used to analyze the risk factors of recurrence after conical resection.

ResultsThe 145 CIN patients were followed up for two years, 30 cases recurrenced, and 115 cases did not recurrence.The results of univariate analysis showed that the postmenopausal status, glandular involvement, CIN pathological grade and postoperatively high-risk human papillomavirus(HPV) infection were correlated with postoperative recurrence(P < 0.05 to P < 0.01), while the age and pregnancy number were not correlated with postoperative recurrence(P>0.05).The results of multivariate logistic regression analysis showed that the menopause, glandular involvement, CIN pathological grade and postoperative HPV infection were the independent risk factors of postoperative recurrence(P < 0.01).

ConclusionsThe postmenopausal status, glandular involvement, pathological grade of CIN, and postoperative HPV infection are the high risk factors for recurrence after conization in high-grade CIN patients.