Effect of clozapine on glucose and lipid metabolism, cognitive function and related factors in the treatment of schizophrenic patients

ObjectiveTo investigate the effects of clozapine on glucose and lipid metabolism, cognitive function and related factors in the treatment of patients with schizophrenia.

MethodsA total of 80 schizophrenic patients were randomly divided into the observation group and control group(40 cases in each group), and the control group and observation group were treated with risperidone tablets and clozapine tablets, respectively.The levels of estradiol(E2), prolactin(PRL), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), total cholesterol(TC), triglyceride(TG) and fasting blood glucose(FPG), and cognitive function scores were compared between two groups.

ResultsAfter intervention, the general psychopathological symptoms, negative symptoms and positive symptoms in two groups were significantly lower than those before intervention(P < 0.01).After intervention, the scores of different dimensions of MCCB scale in two groups increased compared with those before intervention(P < 0.05 to P < 0.01), and the scores of working memory, speech learning and problem reasoning dimensions in observation group were significantly higher than those in control group(P < 0.05 to P < 0.01).Except for HDL-C in the control group, the differences of the levels of blood glucose and blood lipid in two groups between before and after treatment were statistically significant(P < 0.05 to P < 0.01).After intervention, the levels of FPG, TC, TG and LDL-C in observation group were higher than those in control group, while the HDL-C level in observation group was lower than that in control group(P < 0.01).After treatment, the E2 level decreased, and the PRL level increased in the control group(P < 0.01), while there was no statistical significance in the levels of E2 and PRL in the observation group between before and after treatment(P>0.05).After treatment, the PRL level in observation group was lower than that in control group, and the E2 level in observation group was higher than that in control group(P < 0.01).

ConclusionsIn the treatment of schizophrenia, the application of clozapine intervention can improve the patients' cognition, and has little effect on PRL, but it will have a certain impact on glucose and lipid metabolism.