ObjectiveTo investigate the relationship between early plasma N-terminal pro-B-type natriuretic peptide(NT-proBNP) level and disease severity and prognosis in patients with traumatic craniocerebral injury.
MethodsA retrospective research method was used to select 100 patients with traumatic craniocerebral injury as observation group.The plasma NT-proBNP level was recorded at 2, 12 and 24 hours of the onset, and the change was analyzed.According to Glasgow coma scale(GCS) score of patients at admission, patients with traumatic craniocerebral injury were divided into mild group, middle group and severe group.The plasma NT-proBNP level of the three groups was compared at indicated times, and the correlation between plasma NT-proBNP level and disease severity was explored.At 30 d after the onset, the patients with traumatic craniocerebral injury were divided into poor prognosis group and good prognosis group according to the Glasgow outcome scale(GOS) score, and the plasma NT-proBNP level of patients with different prognosis was compared.
ResultsAt 2, 12 and 24 hours, there were significant differences in plasma NT-proBNP levels among the three groups, the mild group was lower than the other two groups, and the middle group was lower than the severe group(P < 0.01).There were significant differences in plasma NT-proBNP levels at 2, 12 and 24 hours of onset in the three groups(P < 0.01).The levels at 12 and 24 hours of onset in the mild group were significantly higher than those at 2 hours of onset(P < 0.01), the levels at 24 hours of onset in the middle group were significantly higher than those at 2 and 12 hours of onset(P < 0.01), the levels at 12 and 24 hours of onset in the severe group were significantly higher than those at 2 hours of onset(P < 0.01), and the levels at 24 hours of onset were significantly higher than those at 12 hours of onset(P < 0.01).At 2, 12 and 24 hours of onset, the NT-proBNP level in the good prognosis group was significantly lower than that in the poor prognosis group(P < 0.01).There were significant differences in NT-proBNP levels between the two groups at different times of onset(P < 0.01).At 12 and 24 hours of onset, both groups were higher than 2 hours of onset(P < 0.01), and the 24 hours of onset in the good prognosis group was higher than 12 hours of onset(P < 0.01).Plasma NT-proBNP was significantly negatively correlated with GCS and GOS scores(P < 0.01).
ConclusionsThe level of plasma NT-proBNP in patients with traumatic craniocerebral injury is significantly increased in the early stage, and its expression level is negatively correlated with GCS and GOS score.The above-mentioned scores can be used to predict the changes of the disease in clinical practice.
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