The value of ALBI and PALBI grades in the prognostic assessment of hepatitis B virus associated HCC patients

ObjectiveTo explore the value of albumin-bilirubin (ALBI) and platelet-albumin-bilirubin (PALBI) grades in the prognostic evaluation of Child-Pugh grade A HCC patients.

MethodsClinical data of 134 Child-Pugh grade A hepatitis B virus associated HCC patients undergoing radical resection were retrospectively analyzed.ALBI and PALBI grades were calculated based on preoperative serologic examination.Overall survival (OS) and recurrence-free survival (RFS) were estimated using Kaplan-Meier curves and Cox regression.

ResultsAfter follow-up, 37 patients died and 35 patients relapsed.Kaplan-Meier analysis showed that ALBI and PALBI grades were significantly correlated with OS and RFS (P < 0.05).Multivariate analysis indicated that both ALBI and PALBI grades were independent prognostic models for patients.Among different scoring systems, PLABI + tumor diameter, ALBI + tumor diameter, and ALBI + Italian liver cancer group score (CLIP) were more significant in predicting prognosis than CLIP, PLABI, ALBI, end-stage liver cancer model score, and Barcelona staging alone.

ConclusionsALBI and PALBI grades are valuable models for evaluating the prognosis of Child-Pugh grade A HCC patients, if when they combine with tumor diameter, PALBI grade has better prognostic value for HCC patients than ALBI grade.