Effect of dexmedetomidine combined with ultrasound-guided TAP block anesthesia on amyloid β-protein and Tau protein in patients undergoing laparoscopic inguinal hernia repair

ObjectiveTo investigate the effect of dexmedetomidine combined with ultrasound-guided transversus abdominis plane(TAP) block anesthesia on the serum level of β-42 amyloid(Aβ-42) and Tau protein in patients undergoing laparoscopic inguinal hernia repair.

MethodsA total of 100 patients undergoing laparoscopic inguinal hernia repair were selected and randomly divided into control group and observation group(50 cases in each group).The control group received laryngeal mask general anesthesia, and the observation group received ultrasound-guided TAP block combined with dexmedetomidine anesthesia.The mean arterial pressure, heart rate(HR) and blood oxygen saturation at the time of skin incision(T1), 1 h at the beginning of operation(T2) and immediate time after operation(T3) were recorded.The pain visual analogue scale(VAS) score, mini-mental state examination(MMSE) score, incidence of postoperative cognitive dysfunction(POCD) and expression levels of Aβ-42 and Tau protein were compared between the two groups.

ResultsThe VAS scores in the two groups decreased gradually at immediate time after operation, 6 h, 24 h and 48 h after operation(P < 0.05), and the VAS scores at 6 h, 24 h and 48 h after operation in observation group were significantly lower than those in control group(P < 0.01).The HR in observation group at T2 and T3 was significantly lower than that in control group(P < 0.01), and HR at T2 and T3 was lower than that at T1(P < 0.05).The incidence of POCD in observation group was 6.00%(3/50), which was lower than 22.00%(11/50) in control group(P < 0.05).The MMSE scores in the two groups at 1 d, 7 d after operation were lower than those before anesthesia(P < 0.05), and which in observation group were significantly higher than those in control group(P < 0.01). The Tau protein level and Tau/Aβ-42 value in the two groups at 7 d after operation were higher than those before anesthesia(P < 0.05), the Aβ-42 protein level was lower than that before anesthesia(P < 0.05), and the Tau protein level and Tau/Aβ-42 value in observation group were lower than that in control group(P < 0.05 and P < 0.01), the Aβ-42 protein level was significantly higher than that in control group(P < 0.01).

ConclusionsUltrasound-guided TAP block anesthesia combined with dexmedetomidine has good analgesic effects in laparoscopic inguinal hernia repair, which can effectively improve the patient's cognitive function, regulate the postoperative serum level of Aβ-42 and Tau protein, and decrease the incidence of POCD.