Relationship between the serum vitamin A and E levels, and onset and severity of preeclampsia

ObjectiveTo investigate the relationship between the serum vitamin A and E levels, and onset and severity of preeclampsia.

MethodsA total of 257 pregnant women with preeclampsia were divided into the mild group(n=104) and severe group(n=153) according to the severity of preeclampsia, and 12 822 normal pregnant women were set as the control group.The serum levels of vitamin A and E, diastolic blood pressure(DBP), systolic blood pressure(SBP), serum creatinine(Scr) and 24-hour urinary protein quantification(24 hpro) were compared among three groups.The correlation of vitamin A and E with DBP, SBP, SCr and 24 hpro were analyzed, and the predictive value of vitamin A and E to preeclampsia was analyzed.

ResultsThe vitamin A and E levels in severe group were significantly lower than those in mild group and control group, and those in mild group were also significantly lower than those in control group(P < 0.01).The DBP, SBP, Scr and 24 hpro in severe group were significantly lower than those in mild group and control group, and those in mild group were significantly lower than those in control group(P < 0.01).The results of Pearson correlation analysis showed that the serum levels of vitamin A and E were negatively correlated with DBP, SBP, SCr, and 24 hpro(P < 0.05).When the cut-off point was 0.35 mg/dL, the sensitivity and specificity of vitamin A to predict the preeclampsia were 63.3% and 60.9%, respectively(P < 0.05).When the cut-off point was 16.85 mg/dL, the sensitivity and specificity of vitamin E to predict the preeclampsia were 72.1% and 69.7%, respectively(P < 0.05).

ConclusionsThe levels of serum vitamin A and E levels are abnormal in pregnant women with preeclampsia, which has a certain correlation with the severity of disease.The levels of serum vitamin A and E should be strictly monitored and controlled.