Clinical study on the evaluation of hepatic space-occupying lesions related to androgen treatment for aplastic anemia by multi-modality image fusion

ObjectiveTo explore the clinical value of multi-modality image fusion in evaluating hepatic space-occupying lesions related to androgen treatment for aplastic anemia (AA).

MethodsTotal 49 patients with AA who had undergone androgen treatment and had hepatic space-occupying lesions detected by ultrasound were selected as the observation group.Meanwhile, 78 patients with the other hepatic space-occupying lesions were selected as the control group.All patients were subjected to spiral CT and MRI scanning.CT and MRI dual-phase images were fused, and the value of multi-modality image fusion in evaluating hepatic space-occupying lesions related to androgen treatment for AA was analyzed.

ResultsSerum biological examination, puncture, postoperative histopathological examination or more than 6 months of clinical and imaging follow-up found that there were 45 cases with 68 hepatic space-occupying lesions in the observation group and 75 cases with 92 hepatic space-occupying lesions in the control group.The proportion of benign lesions in the observation group was higher than that in the control group (P < 0.05).The proportion of lesions detected by fusion images was higher than that by CT in the observation group (P < 0.05), and the proportion of lesions detected by fusion images was higher than that by CT or MRI in the control group (P < 0.05), but the proportion of lesions detected by fusion images in the observation group was not significantly different from that in MRI examination (P>0.05).Taking surgical results, pathological results or follow-up results as the golden standard, the sensitivity, specificity and accuracy of spiral CT, MRI and fusion images to diagnose hepatic space-occupying lesions related to androgen treatment for AA were (71.43%, 87.50%, 80.00%), (85.00%, 88.00%, 86.67%) and (100.00%, 94.74%, 97.78%), respectively.The diagnostic value of fusion images was higher than that of CT or MRI (P < 0.05).

ConclusionsMulti-modality image fusion has good diagnostic value in evaluating the hepatic space-occupying lesions related to androgen therapy in aplastic anemia.It can improve the detection rate of hepatic space-occupying lesions, and its diagnostic efficiency is better than that of CT or MRI.It is worthy of clinical promotion and application.