Expression and clinical significance of sCD86 and HMGB1 in peripheral blood of children with allergic rhinitis

ObjectiveTo explore the expression and clinical significance of soluble CD86(sCD86) and high mobility group protein B1(HMGB1) in peripheral blood of children with allergic rhinitis.

MethodsA total of 150 children with allergic rhinitis were selected as the observation group.They were divided into mild group(n=112) and moderate to severe group(n=38) according to the severity of the disease, and 50 normal children who underwent physical examination in the same period were selected as the control group.The levels of immunoglobulin E(IgE), interleukin-4(IL-4), interleukin-9(IL-9), interferon-γ(IFN-γ), sCD86 and HMGB1 in each group were compared.In the observation group, the sCD86, HMGB1 levels and IgE, IL-4, IL-9, IFN-γ levels were analyzed by univariate, logistic multivariate and correlation analysis.

ResultsIgE, IL-4, IL-9, sCD86 and HMGB1 levels in the observation group were significantly higher than that in the control group; IFN-γ levels were significantly lower than that in the controls group(P < 0.01).Moreover, IgE, IL-4, IL-9, sCD86 and HMGB1 levels in the moderate to severe group were significantly higher than those in the mild group; IFN-γ levels were significantly lower than that in the mild group(P < 0.01).IgE, IFN-γ, IL-4, IL-9, sCD86 and HMGB1 were the independent influencing factors for the severity of allergic rhinitis(P < 0.05 to P < 0.01).In sera from children with allergic rhinitis, sCD86 and HMGB1 levels were positively correlated with IgE, IL-4 and IL-9(P < 0.05), and negatively correlated with IFN-γ(P < 0.05).

ConclusionsThe high expression of sCD86 and HMGB1 in serum of children with allergic rhinitis may be related to IgE mediated type Ⅰ allergy and Th1/Th2 cell imbalance.