Analysis of correlation between four-item urinary proteins combined with serum UA, FT3 and early kidney injury of hypertension

ObjectiveTo detect the levels of four-item urinary proteins and blood indexes in patients with early kidney injury of hypertension, and to explore their correlations with early kidney injury of hypertension and its clinical value in the treatment of patients with early kidney injury of hypertension.

MethodsSixty patients with hypertension were selected as the study subjects.They were divided into hypertension microalbuminuria group (n=30) and simple hypertension group (n=30) according to urinary microalbumin (mAlb) to urinary creatinine (Ucr) ratio (ACR).Meanwhile, 30 healthy adults were selected as control group.And the corresponding urinary mAlb, β2-microglobulin (β2-MG), transferrin (TRF), immunoglobulin G (IgG), serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), uric acid (UA), serum urea (UREA) and creatinine (Scr) were detected, respectively.

ResultsThe urinary mAlb, β2-MG, TRF, IgG, serum concentrations of UA, UREA and Scr in the hypertension microalbuminuria group were high than those in both the control group and simple hypertension group (P < 0.01).There was no significant difference in the urinary mAlb, β2-MG, TRF, IgG, serum concentrations of UA, UREA, Scr between the simple hypertension group and the control group (P>0.05).Compared with the control group, the levels of FT3 in both simple hypertension group and hypertension microalbuminuria group were decreased (P < 0.01).Pearson correlation analysis showed that mAlb, β2-MG, TRF, IgG and UA in hypertension microalbuminuria group were positively correlated with ACR, UREA and Scr (P < 0.05), and FT3 was negatively correlated with ACR, UREA and Scr (P < 0.01).

ConclusionsUrinary mAlb, β2-MG, TRF, IgG and serum concentrations of UA, FT3 can serve as effective indexes for the early kidney injury of hypertension.