Early diagnosis and treatment of prostate cancer based on PSA screening

ObjectiveTo investigate the level of prostate specific antigen (PSA) in elderly men over 60 years old in Yangzhou, and explore the relationship between PSA screening and early diagnosis and treatment of prostate cancer.

MethodsThe detailed inclusion and exclusion criteria was formulated, and 3 102 elderly men over 60 years old who underwent physical examination in Yangzhou from May to July 2020 with complete follow-up information were selected.The serum PSA level was detected by chemiluminescent enzyme immunoassay.The patients who met the prostate cancer puncture criteria were subjected to transperineal prostate biopsy guided by B-ultrasound, and Gleason score was performed.

ResultsWith the increase of age, the proportion of abnormal PSA level increased significantly (P < 0.01).A total of 62 elderly patients underwent prostate biopsy, of which 38 patients had PSA between 4-10 ng/mL, and 14 patients (36.8%) were diagnosed as cancer; PSA>10 ng/mL in 24 cases, and 15 (62.5%) cases were diagnosed as cancer by puncture.With the increase of PSA level, the proportion of positive prostate puncture increased (P < 0.05).According to the tumor staging of puncture positive subjects, with the increase of PSA, the higher the Gleason score of tumor and the greater the risk coefficient (P < 0.05).

ConclusionsWith the increase of age, PSA shows an upward trend, and the higher the level of PSA, the greater the possibility of prostate cancer, and the higher the degree of malignancy.Early and regular PSA examination is recommended for elderly men.